A series of condensed 4-substituted aryl 2-4-substituted phenloxy methyl 4-oxazol-5-ones (1-12) have been synthesized by condensation of the aryloxy acetyl-amino-acetic acids with suitable aldehydes. The synthesized compounds were evaluated for the antibacterial activity against bacterial strains Escherichia coli (gram negative), staphylococcus aureus (gram positive) and antifungal activity against Aspergillus fumigatus. The aim of this study was to investigate the effect of various substitutions at C-2 and C-4 positions of the oxazolone on antimicrobial activities. Norfloxacine (NOR) and Fluconazole (FL) were used as reference standards. Most of the synthesized compounds showed significant antibacterial activity against gram positive bacteria and antifungal activity; however none of the compounds showed activity against gram negative bacteria.
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